|
KMID : 0981820100300020117
|
|
Korean Journal of Laboratory Medicine
2010 Volume.30 No. 2 p.117 ~ p.121
|
|
|
Clathrin Assembly Lymphoid Myeloid Leukemia-AF10-positive Acute Leukemias: A Report of 2 Cases with a Review of the Literature
|
|
Huh Ji-Young
Chung So-Ie
Oh Do-Yeun
Kang Myung-Seo
Eom Hyeon-Seok
Cho Eun-Hae
Han Mi-Hwa
Kong Sun-Young
|
|
|
Abstract
|
|
|
|
The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with the AF10 gene; these genes are present on chromosomes 11 and 10, respectively. Because the CALM-AF10 rearrangement is a rare chromosomal abnormality, it is not included in routine molecular tests for acute leukemia. Here, we describe the cases of 2 patients with the CALM-AF10 fusion gene. The first patient (case 1) was diagnosed with T-cell ALL, and the second patient (case 2) was diagnosed with AML. Both patient samples showed expression of the homeobox A gene cluster and the histone methyltransferase hDOT1L, which suggests that they mediate leukemic transformation in CALM-AF10-positive and mixed-lineage leukemia-AF10-positive leukemias. Both patients achieved complete remission after induction chemotherapy. The first patient (case 1) relapsed after double-unit cord blood transplantation; there was no evidence of relapse in the second patient (case 2) after allogenic peripheral blood stem cell transplantation. Since CALM-AF10- positive leukemias have been shown to have poor prognosis with conventional therapy, molecular tests for CALM-AF10 rearrangement would be necessary to detect minimal residual disease during follow-up. (Korean J Lab Med 2010;30:117-21)
|
|
|
KEYWORD
|
|
|
t(10, 11), CALM-AF10, HOXA gene, hDOT1L, Acute leukemia, Reverse transcriptase-PCR
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|